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While administration of glucocorticoids may lead to dendritic atrophy and reduction in number of synapsis in the hippocampus and PFC, survival of neurons may be enhanced by downstream regulation of glucocorticoids by major neurotrophic factors such as (BDNF) which plays a role in regulation and function of neurons (141145)

Nevertheless, it remains unknown whether hydrochlorothiazide or thiazide-like diuretics reduce GLP-1 responses, glucose tolerance, energy intake behavior and feeding patterns in the long term

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An overview of autophagy: mechanism, regulation and research progress

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